BioBASE AP is a bioresorbable Bone Substitute for the Augemtation of Bone Defects α-Tricalcium phosphate. BioBASE is a synthetic Granulate consisting of phase-pure α-tricalcium phosphate. Over the last 20 years BioBASE has been clinically tested in a very wide range of indications.

BioBASE AP has been licensed by the German Federal Health Office (published in the Federal Gazette Volume 43, Nr. 90, 17.05.1991, p. 3269) and is thus the first bioactive, resorbable bone substitute to be approved in the Federal Republic of Germany.

BioBASE AP fufills the requiremtents of the “ASTM F 1088-87” - “TCP for Surgical Impantation”. Only a few pure ɑ-tricalcium phosphate without non-resorbable hydroxyapatite components. It exhibits excellent bioactive properties:

A special surface modification, charracteristic of BioBASE AP, leads to increased calcium elution during the initial phase of the healing process which, in turn, stimulates resorption and bone regeneration at the defect site.

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  • Filling of defects following exstirpation of bone cysts
  • Filling of extraction defects for the creation of an implant bed
  • Filling of defects in the case of corrective osteotomy
  • Other multi-layer bone defects of the alveolar processes and the facial skull
  • Periodontal defects, also in connection with membranes
  • Defects following the extraction of impacted teeth
  • Defects following apicoectomy
  • Sinus floor elevation
  • Filling of gaps between the alveolar cavity and the implant

Figure 1: The microporosity is visible in this enlargement.

Figure 2: Microporosity in detail, pores up to approx. 5 μm; sinter necks are discernible.


It is advisable to apply BioBASE AP in a moist state. The patient's own blood or blood plasma should be used. If neither option is available in sufficient quantities, a sterile isotonic saline solution may be used.

Where defects are larger than approx. 2 cm³ it is advisable to mix BioBASE AP with spongiosa.

Local administration of antibiotics is possible.

Figure 3: BioBASE AP mixed with autologous blood.

Figure 4: Apical defect in the maxilla.

Figure 5: Defect filled with BioBASE AP.

Figure 6: After the healing of the defect.