BioBASE is a bioresorbable bone replacement from microporous and macroporous α-tricalcium phosphate. Biobase is an inorganic, bioresorbable bone replacement from pure-phase α-tricalcium phosphate.

BioBASE is a bone replacement for temporarily filling pathological, traumatic and postoperative bone defects. Biobase has a system of micropores (< 5 μm) and macropores (max. 1 mm) with a porosity of approx. 65%. This creates a far larger material surface, which enhances the reaction kinetics in the resorption processes. Biobase has a special surface structure which increases the level of calcium elution, and promotes ossification. BioBASE is broken down to the same extent as it forms new bones. Duration of resorption: 6 to 14 months.

Blood vessels and osteoblasts grow in the macropores and guarantee rapid proliferation of the new bone substance.

Tissue fluid penetrates the pore system, thereby enabling a complete hydrolitic breakdown of the material.

BioBASE acts as a conductor for the proliferating bones by producing an osteoconductive effect.

The constant and precise composition with a calcium-phosphorus atomic ratio of 1.5 is very similar to the calcium-phosphorus atomic ratio of the mineral phase of the human bone of 1.6 and guarantees the high degree of biocompatibility of BioBASE.

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Addition of the material to autogenic or allogenic spongiosa to reconstruct bone defects e.g. in cases of spondylodesis, vertebral body replacement and in joint replacement surgery.

  • Filling defects in correction osteotomies
  • Filling the sites from which autogenic bones have been removed
  • Filling bone cysts
  • Use in cases of arthrodesis
  • Filling defects after the removal of benign bone tumours

Figure 1: The microporosity is visible in this enlargement.

Figure 2: Microporostiy in detail, pores up to approx. 5 μm; sinter necks are discernible.


It is advisable to apply BioBASE in a moist state. The patient’s own blood or blood plasma should be used. If neither option is available in sufficient quantities, a sterile isotonic saline solution may be used.

A mixture of BioBASE and spongiosa in a ratio of 1:1 is recommended to fill larger defects (> 2 cm³).

Local administration of antibiotics is possible.

Figure 3: Dysplasia, proximal tibia.
Figure 4: Debridement of the fibrosis, filling the defect with BioBASE.

Figure 5: After 8 months: visible osseous reorganisation of the granules.
Figure 6:
After 13 months: bony growth and start of resorption.