BioBASE is a bioresorbable bone replacement from microporous and macroporous α-tricalcium phosphate. Biobase is an inorganic, bioresorbable bone replacement from pure-phase α-tricalcium phosphate.
BioBASE is a bone replacement for temporarily filling pathological, traumatic and postoperative bone defects. Biobase has a system of micropores (< 5 μm) and macropores (max. 1 mm) with a porosity of approx. 65%. This creates a far larger material surface, which enhances the reaction kinetics in the resorption processes. Biobase has a special surface structure which increases the level of calcium elution, and promotes ossification. BioBASE is broken down to the same extent as it forms new bones. Duration of resorption: 6 to 14 months.
Blood vessels and osteoblasts grow in the macropores and guarantee rapid proliferation of the new bone substance.
Tissue fluid penetrates the pore system, thereby enabling a complete hydrolitic breakdown of the material.
BioBASE acts as a conductor for the proliferating bones by producing an osteoconductive effect.
The constant and precise composition with a calcium-phosphorus atomic ratio of 1.5 is very similar to the calcium-phosphorus atomic ratio of the mineral phase of the human bone of 1.6 and guarantees the high degree of biocompatibility of BioBASE.
Addition of the material to autogenic or allogenic spongiosa to reconstruct bone defects e.g. in cases of spondylodesis, vertebral body replacement and in joint replacement surgery.
Figure 1: The microporosity is visible in this enlargement.
Figure 2: Microporostiy in detail, pores up to approx. 5 μm; sinter necks are discernible.
It is advisable to apply BioBASE in a moist state. The patient’s own blood or blood plasma should be used. If neither option is available in sufficient quantities, a sterile isotonic saline solution may be used.
A mixture of BioBASE and spongiosa in a ratio of 1:1 is recommended to fill larger defects (> 2 cm³).
Local administration of antibiotics is possible.
Figure 3: Dysplasia, proximal tibia.
Figure 4: Debridement of the fibrosis, filling the defect with BioBASE.
Figure 5: After 8 months: visible osseous reorganisation of the granules.
Figure 6: After 13 months: bony growth and start of resorption.